Sodium acetate in Clinical Pharmacology
Sodium is a principal cation of extra-cellular fluid. It comprises of more then 90 percent of total cations in its normal plasma concentration of an estimate of 140 mEq/ liter. The ion of sodium plays a major role in controlling the total body water and its distribution.
Acetate (CH3COO) is a hydrogen ion receptor. It also serves as an alternate source of bicarbonate(HCO3) by metabolic alteration in the liver. The conversion has been shown to advance, even in the presence of liver diseases.
Sodium acetate Injection:
USP (2 mEq/ml) is a sterile, nonpyrogenic, concentrated solution of sodium acetate present in water form in
the injection. The solution is administered after dilution by the intravenous route as an electrolyte replenisher.
Each ml contains 164 mg of sodium acetate (anhydrous) which would provide about 2 mEq each of sodium (Na+) and acetate (CH3COO. It may also contain acetic acid for pH adjustment; approximate pH- 6.5. The osmolar concentration is 4mOsmol/ml (calc.). A pharmacy bulk package is a container of sterile preparation for parental use that contains many single doses.
The contents are intended for the use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. The solution is intended as an alternative to sodium chloride in order to provide sodium ion (Na+) for addition to large volume infusion fluids for intravenous use.
Sodium acetate injection USP (2 mEq/ml) is indicated as a source of sodium for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions.
Sodium is a principal cation of extra-cellular fluid. It comprises of more then 90 percent of total cations in its normal plasma concentration of an estimate of 140 mEq/ liter. The ion of sodium plays a major role in controlling the total body water and its distribution.
Acetate (CH3COO) is a hydrogen ion receptor. It also serves as an alternate source of bicarbonate(HCO3) by metabolic alteration in the liver. The conversion has been shown to advance, even in the presence of liver diseases.
Sodium acetate Injection:
USP (2 mEq/ml) is a sterile, nonpyrogenic, concentrated solution of sodium acetate present in water form in
the injection. The solution is administered after dilution by the intravenous route as an electrolyte replenisher.
Each ml contains 164 mg of sodium acetate (anhydrous) which would provide about 2 mEq each of sodium (Na+) and acetate (CH3COO. It may also contain acetic acid for pH adjustment; approximate pH- 6.5. The osmolar concentration is 4mOsmol/ml (calc.). A pharmacy bulk package is a container of sterile preparation for parental use that contains many single doses.
The contents are intended for the use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. The solution is intended as an alternative to sodium chloride in order to provide sodium ion (Na+) for addition to large volume infusion fluids for intravenous use.
Sodium acetate injection USP (2 mEq/ml) is indicated as a source of sodium for addition to large volume intravenous fluids to prevent or correct hyponatremia in patients with restricted or no oral intake. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions.
No comments:
Post a Comment